He usually saves his beefs for other rappers; this time, 50 Cent is going after Oprah Winfrey.

In an interview with The Associated Press, 50 complained that Winfrey rarely invites rappers on her talk show: “I think she caters to older white women.”

“Oprah’s audience is my audience’s parents,” the 29-year-old rapper said. “So, I could care less about Oprah or her show.”

He’s not alone in his resentment toward the talk show host cum media mogul.

Rapper-actor Ludacris, aka Chris Bridges, said in the May issue of GQ magazine that Winfrey was “unfair” during a show he appeared on last October with co-stars from best-picture Oscar winner “Crash.”